CLL MRD Group

AIM: To develop standardised methods for MRD analysis by flow cytometry and RQ-ASO IgH-PCR that are:

• Broadly applicable
• Have a defined specificity and sensitivity
• Standardised reporting convention

Current flow cytometry assay status:

• Limit of detection 0.01% for typical CLL
  • Accuracy 95.7%
  • Sensitivity 91.1%
  • Specificity 98.8%